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Comprehensive Solutions for Apoptosis Research
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★In vitro and in vivo anti-cancer drug screening and
evaluation
KeyGen has built the cancer
cell bank with aver 150 different cell lines for cancer research and anti-cancer
drug development. This cancer cell bank includes human head and neck cancer, respiration
system cancer, digestive system cancer, women cancer and urological system cancer,
nerve system cancer, blood cancer and sarcoma, melanoma, etc. Besides human cancer
cell lines, KeyGen cell bank also includes the cancer cell lines and normal cell
lines from other species such as mouse, rats, hamster, monkey, dog, etc. KeyGen
has also setup the experimental animal center with 600 mm2 at specific pathogen
free conditions (SPF) level suitable for nude mice and SCID mice raising, which
guarantees the in vivo activity evaluation, preliminary toxicity evaluation and
drug discovery.
★Cell apoptosis detection techniques
To induce cancer cell apoptosis is
an important strategy for anti-cancer new drug development. KeyGen has setup multiple
methods for cell apoptosis detection by making use of KeyGen’s cancer cell bank.
About twenty cell apoptosis detection kits have been successfully developed. The
high-throughput anti-cancer new drug screening technique has been developed based
on cancer cell apoptosis, which will enable the screening and discovery of cancer
cell apoptosis inducer.
On this platform KeyGen provides the services
based on the resources as following：
Human Tumor Cell Lines For In vitro and In vivo Anti-cancer Drug Screening
Scientific service items
（1）、In vitro and in vivo anti-cancer
drug screening and evaluation
KeyGen has multiple research models at cellular or molecular level, experimental animal base with SPF facilities, which provide the environment for anti-cancer drug screening and evaluation for clients from all over the world.
| Name of the models |
| a、In vivo model using nude mice bearing cancer for anti-cancer drug evaluation |
| b. In vivo angiogenesis model for anti-cancer drug evaluation |
| c、In vitro cancer cell growth inhibition model/td> |
| d、Cell apoptosis model |
| …… |
（2）、Customer service of preparation
of nude mice bearing cancer
KeyGen has setup the SPF facilities for anti-cancer
drug evaluation using nude mice. We can provide services of the preparation of nude
mice bearing different cancer cells originated from different human tissue, which
will enable the further in vivo anti-cancer evaluation.
（3）、Acute
toxicity evaluation
KeyGen provides the studies of acute toxicity evaluation with the drug given by different routes such as oral, i.v., i.p., etc. The reports of half lethal dosage (LD50) and maximum tolerance dosage.
The prices of services are as follows:
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Service | Price |
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In vitro anti-cancer drug screening and evaluation |
one drug (five different doses) using one cancer cell line costs 600$. |
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In vivo anti-cancer drug screening and evaluation |
one drug (three different doses) using one cancer cell nude mice xenograft model costs 12,000$. |
| Acute toxicity evaluation |
one drug costs $3,000 USD. |
There is an example of a report on anticancer effect of three
topotecan derivatives in nude mice xenograft model we had done for our client. |
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